Metal Gear Solid on PS1 originally had Solid Snake befriending rats.
According to a new video by YouTube channel Did You Know Gaming (narrated by David Hayter no less), game director Hideo Kojima wanted to add more rats into the game, allowing the player to assign them names and raise them as pets.
Rats were apparently the first life forms Snake encounters in the cold of Alaska, and would play an important role in the game.
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